Reference Library

The references below will provide education and information on stem cells and treatments that form the foundation for the protocols currently used in regenerative medicine.

  • 1. P. Zuk, et al. Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies. TISSUE ENGINEERING 2001;7:212-228.
  • 2. I. Hong, et al. Isolation and culture methods of adipose-derived stem cells. IFATS 2009 Oral Abstracts;17.
  • 3. K. Yoshimura, et al. Cell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells. Aesth Plast Surg 2008;32:48-55.
  • 4. K. Yoshimura, et al. Cell-Assisted Lipotransfer for Facial Lipoatrophy: Efficacy of Clinical Use of Adipose-Derived Stem Cells. Dermatol Surg 2008;34:1178-1185.
  • 5. H. Suga, et al. Numerical Measurement of Viable and Nonviable Adipocytes and Other Cellular Components in Aspirated Fat Tissue. Plast. Reconstr. Surg. 2008;122:113.
  • 6. J. Mitchell, et al. Immunophenotype of Human Adipose-Derived Cells: Temporal Changes in Stromal-Associated and Stem Cell-Associated Markers. STEM CELLS 2006;24:380.
  • 7. D. Alderman, et al. Stem Cell Prolotherapy in Regenerative Medicine
  • 8. JOURNAL of PROLOTHERAPY. 2001; 3:3
  • 9. Dhinsa BS, Adesida AB. Current clinical therapies for cartilage repair, their limitation and the role of stem cells. Curr Stem Cell Res Ther. 2012 Mar;7(2):143-8.
  • 10. J. Pak, et al. Regenerative Repair of Damaged Meniscus with Autologous Adipose Tissue-Derived Stem Cells study. Biomed Res Int. 2014; 2014: 436029
  • 11. D. Alderman, et al. Stem Advances in Regenerative Medicine: High-Density Platelet-Rich Plasma and Stem Cell Prolotherapy for Musculoskeletal Pain. Practical Pain Management 2011; 49-63
  • 12. A. Parker, et al. Adipose-Derived Stem Cells For the Regeneration of Damaged Tissues. Expert Opin. Biol. Ther. (2006) 6(6)
  • 13. S. Guiducci, et al. Autologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic Sclerosis. Annals of Internal Medicine. 2010; 153:10.
  • 14. J. Gimble, et al. Adipose Tissue as a Source for Musculo-Skeletal Regeneration. Front Biosci (Schol Ed). 2011; 3: 69-81.
  • 15. J. Gimble, et al. Adipose Derived Stem Cellsfor Regenerative Medicine. Circ Res. 2007;100:1249-1260.
  • 16. M. Sun,et al. Adipose-Derived Stem Cells Improved Mouse Ovary Function After Chemotherapy-Induced Ovary Failure.
  • 17. E. Vescarelli, et al. Adipose Derived Stem Cells: An Innovative Therapeutic Approach in Systemic Sclerosis and Parry-Romberg Syndrome.
  • 18. H. Orabi, et al. Adipose Derived Stem Cells for Treatment of Lower Genitourinary Dysfunction. Orabi et al., J Stem Cell Res Ther 2014, 4:4
  • 19. Gir P., et al. Human Adipose Stem Cells: Current Clinical Applications. Plast Reconstr Surg. 2012 Jun;129(6):1277-90.
  • 20. Baer PC, Geiger H. Adipose-derived mesenchymal stromal/stem cells: tissue localization, characterization, and heterogeneity. Stem Cells Int. 2012:812693
  • 21. G. Yu, et al. Isolation of Human Adipose-Derived Stem Cells from Lipoaspirates. Methods in Molecular Biology, vol. 702, DOI 10.1007/978-1-61737-960-4_2
    • FAQ

      Q: What is Regenerative Medicine?

      A: One of the principal features of regenerative medicine is using your own tissue, stem cells and other regenerative cells, to assist the natural healing process. Ultimate tissue repair and improved function are the goals of regenerative treatments.

      Q: What are Stem Cells?

      A: Stem cells are the body's very own internal repair system. They are the foundation of development in living organisms. These undifferentiated cells help mend the body and heal tissue.

      Stem cells have a unique set of properties that set them apart from other kinds of cells in the human body.

      Stem cells can REGENERATE to replace damaged cells.

      Stem cells can REPLICATE many times for long periods.

      Stem cells are unspecialized and can DEVELOP into different types of cells.

      Q: What is the Process of Stem Cell Therapy?

      A: Upon obtaining a small adipose "fat" aspiration, stem cells are extracted and concentrated and given back to you by an intravenous infusion or by direct injection into injured joints or other damaged areas.

      Q: Will Stem Cells Help Surgical Healing?

      A: There is evidence supporting the use of stem cells during or after surgery in order to accelerate recovery. Ask your surgeon if your surgical procedure could potentially benefit with the addition of stem cell therapy simultaneously.

      Q: What Should I Expect Day of Treatment?

      A: Generally "stem cell" injection care is provided as outpatient care meaning no need for overnight stay (unless surgery was also planned). However, your physician may recommend brief conscious sedation for comfort purposes. Soreness or discomfort for a few days after procedure is not unusual. Pain medication is rarely necessary for donor or injection site. Everyone's response to stem cell injection care is different and likely depends upon severity of injured tissue being repaired.

      Q: What Should I Expect After Procedure?

      A: There may be some discomfort for 48-72 hours post procedure. We recommend rest and no exercise for 72 hours. Gradual return to regular activities may begin at 1-2 weeks post treatment. Your physician may require physical therapy as a guided assist in an effort toward re-establishing motion and function.

      Q: Are Stem Cells FDA Approved?

      A: The FDA has the authority to regulate stem cell products in the United States. With limited exceptions, investigational products must also go through a thorough FDA review process as investigators prepare to determine the safety and effectiveness of products in well-controlled human studies, called clinical trials. The FDA has reviewed many stem cell products for use in these studies.

      Q: Will My Insurance Cover Stem Cell Injection Care?

      A: Stem cell treatments are not generally covered by Medicare and insurance carriers.

      What To Expect From a Stem Cell Treatment

      Stem cells are not used to treat, diagnose, or cure any disease as a first-line treatment. However, stem cells have the potential to treat a wide range of diseases. If a first-line therapy either fails to resolve the symptoms or produces intolerable side effects, you may then elect investigational modalities of treatment such as stem cell therapy. The potential benefits of autologous stem cell for eligible patients may include improvement in certain chronic degenerative diseases, and the results and degree of benefit vary by patients. The most widely used areas being studied are chronic degenerative, autoimmune, cardiac, and inflammatory conditions.

      We will contact your primary physician to collect your medical history, labs, and other studies in order to learn about your condition, and to determine if you are a candidate for a stem cell treatment. In doing so, we discuss your planned treatment with your doctor and engage him/her in your care going forward. WE do not work with agents or insurance or third party payers. And therefore, you do not need a referral to seek treatment from one of your network doctors in the traditional sense.

      There is very little if any discomfort in having a stem cell procedure. We do perform a small 50-100cc liposuction from your lower abdomen or flanks under local anesthesia. This lipo aspirate will be used in order to isolate stem cells. You will have the option of an oral or IV sedatives to minimize any discomfort. Most if not all patients elect to have a light IV anesthesia for the procedure.

      The procedure takes just about 2 hours to perform. You will spend a short time in consultation with the nursing staff and your doctor both before and after the procedure. Plan on spending the entire morning or the afternoon with us! Please plan on having someone drive you to the facility and pick you up. You will not be allowed to drive yourself or take a share ride home.